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Original uncropped western blot bands used in this study. ( A ) Inhibition of PITX1 decreased the protein expression level of PFKP in the breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A), as revealed by western blot analysis. ( B ) Western blot analysis revealed downregulation of PFKP protein levels in breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A) after <t>isoliquiritigenin</t> treatment.
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Original uncropped western blot bands used in this study. ( A ) Inhibition of PITX1 decreased the protein expression level of PFKP in the breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A), as revealed by western blot analysis. ( B ) Western blot analysis revealed downregulation of PFKP protein levels in breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A) after <t>isoliquiritigenin</t> treatment.
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Original uncropped western blot bands used in this study. ( A ) Inhibition of PITX1 decreased the protein expression level of PFKP in the breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A), as revealed by western blot analysis. ( B ) Western blot analysis revealed downregulation of PFKP protein levels in breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A) after <t>isoliquiritigenin</t> treatment.
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Original uncropped western blot bands used in this study. ( A ) Inhibition of PITX1 decreased the protein expression level of PFKP in the breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A), as revealed by western blot analysis. ( B ) Western blot analysis revealed downregulation of PFKP protein levels in breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A) after <t>isoliquiritigenin</t> treatment.
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Original uncropped western blot bands used in this study. ( A ) Inhibition of PITX1 decreased the protein expression level of PFKP in the breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A), as revealed by western blot analysis. ( B ) Western blot analysis revealed downregulation of PFKP protein levels in breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A) after isoliquiritigenin treatment.

Journal: Oncology Research

Article Title: Isoliquiritigenin Impedes Breast Cancer Progression through PITX1–PFKP-Mediated Glycolysis Reprogramming

doi: 10.32604/or.2026.077059

Figure Lengend Snippet: Original uncropped western blot bands used in this study. ( A ) Inhibition of PITX1 decreased the protein expression level of PFKP in the breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A), as revealed by western blot analysis. ( B ) Western blot analysis revealed downregulation of PFKP protein levels in breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A) after isoliquiritigenin treatment.

Article Snippet: Isoliquiritigenin (ISL) was purchased from MedChemExpress (MCE, Monmouth Junction, NJ, USA; Cat. No. HY-N0373).

Techniques: Western Blot, Inhibition, Expressing

Isoliquiritigenin inhibits the proliferation and metastatic ability of breast cancer cells via targeting PITX1–PFKP-mediated glycolysis reprogramming. ( A ) Chemical structure of isoliquiritigenin. ( B ) Isoliquiritigenin treatment significantly downregulated PITX1 expression in breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A). ( C ) CCK-8 assay showing reduced proliferation rates in MDA-MB-231, MCF-7, SKBR3, and MCF-10A cells following isoliquiritigenin treatment. ( D , E ) Colony formation assays revealed that isoliquiritigenin significantly inhibited clonogenic potential in MDA-MB-231, MCF-7, SKBR3, and MCF-10A cells. ( F ) Transwell assays demonstrated reduced migratory capacity of MDA-MB-231 cells after isoliquiritigenin-induced PITX1 inhibition. Scale bar: 50 μm. ( G ) Glucose uptake was decreased in MDA-MB-231, MCF-7, SKBR3, and MCF-10A cells following isoliquiritigenin treatment. ( H ) Lactate production was reduced in all three cell lines upon PITX1 inhibition. ( I ) Western blot analysis revealed downregulation of PFKP protein levels in MDA-MB-231, MCF-7, SKBR3, and MCF-10A cells after isoliquiritigenin treatment. * p < 0.05, ** p < 0.01, *** p < 0.001.

Journal: Oncology Research

Article Title: Isoliquiritigenin Impedes Breast Cancer Progression through PITX1–PFKP-Mediated Glycolysis Reprogramming

doi: 10.32604/or.2026.077059

Figure Lengend Snippet: Isoliquiritigenin inhibits the proliferation and metastatic ability of breast cancer cells via targeting PITX1–PFKP-mediated glycolysis reprogramming. ( A ) Chemical structure of isoliquiritigenin. ( B ) Isoliquiritigenin treatment significantly downregulated PITX1 expression in breast cancer cells (MDA-MB-231, MCF-7, SKBR3) and non-tumorigenic breast epithelial cells (MCF-10A). ( C ) CCK-8 assay showing reduced proliferation rates in MDA-MB-231, MCF-7, SKBR3, and MCF-10A cells following isoliquiritigenin treatment. ( D , E ) Colony formation assays revealed that isoliquiritigenin significantly inhibited clonogenic potential in MDA-MB-231, MCF-7, SKBR3, and MCF-10A cells. ( F ) Transwell assays demonstrated reduced migratory capacity of MDA-MB-231 cells after isoliquiritigenin-induced PITX1 inhibition. Scale bar: 50 μm. ( G ) Glucose uptake was decreased in MDA-MB-231, MCF-7, SKBR3, and MCF-10A cells following isoliquiritigenin treatment. ( H ) Lactate production was reduced in all three cell lines upon PITX1 inhibition. ( I ) Western blot analysis revealed downregulation of PFKP protein levels in MDA-MB-231, MCF-7, SKBR3, and MCF-10A cells after isoliquiritigenin treatment. * p < 0.05, ** p < 0.01, *** p < 0.001.

Article Snippet: Isoliquiritigenin (ISL) was purchased from MedChemExpress (MCE, Monmouth Junction, NJ, USA; Cat. No. HY-N0373).

Techniques: Expressing, CCK-8 Assay, Inhibition, Western Blot